Be Excellent To Each Other

THE cervical cancer vaccine may be riskier and more deadly than the cancer it is designed to prevent, a leading expert who developed the drug has warned.

"Cervarix® and Gardasil®, 2 human papillomavirus (HPV) vaccines, have been approved and implemented globally in young adolescent women with the hope of reducing the incidence of cervical cancer several decades hence. This program is dependent on the concept of 'immunobridging': antibody titers generated in young adolescents that are the same or higher than generated in HPV-naive 16- to 26-year-old women, the population in which efficacy is proven. Likewise, realizing a decline in cervical cancer from young adolescent female vaccination depends on the duration of vaccine efficacy, and the population coverage reached. While we patiently wait for results from our young adolescent vaccination programs, newly released data indicates that the immunogenicity and efficacy of the vaccines for young adult women with prior HPV exposure is equal or superior to that seen for young adolescents. This same concept of immunobridging supported by limited efficacy data offers the potential to reduce cervical cancer precursors within just a few years in our young sexually active adult women, a population secondary to our young adolescents. The HPV vaccines are not therapeutic. Neither vaccine will inhibit an already HPV-infected basal epithelial cell which continues to transform differentiated epithelial layers into cervical dysplasias. There is a clinical hope, though, already supported by early data, that the vaccines are capable of neutralizing HPV virions in host tissues from both auto-inoculated infections and infections in other organs than the cervix, thereby making it possible for these vaccines to prevent less common HPV-associated cancers of the penis, vagina, vulva, anus, oral cavity and oro-pharynx. Both vaccines have been shown to be generally safe in the phase II and phase III randomized controlled trials over 3-6.4 years. Post-marketing surveillance of Cervarix and Gardasil continues to show that they are safe for most women despite rarely occurring serious events."

"Cervical cancer of both squamous and adenocarcinoma types is considered virtually 100% attributable to human papillomavirus (HPV) infection. HPV-16 and -18 are the predominant types worldwide accounting for over 70% of all cervical cancer. Persistent oncogenic HPV infection has been confirmed as one key determinant in the development of cervical precancer (cervical intraepithelial neoplasia [CIN] 2+) and cervical cancer. The impact of prophylactic HPV vaccination on the reduction of virological and cytohistological outcomes related to HPV-16 and -18 has been evaluated in clinical trials with the HPV-16/18 AS04-adjuvanted cervical cancer vaccine (Cervarix™) through a Phase IIb study with a long-term follow-up of efficacy up to 5.5 years, and a large Phase III trial in women 15–25 years of age. These individual studies include populations with different underlying risk factors, each of which shows high efficacy against both HPV-16/18 persistent infections and CIN2+. When the two studies are combined and the respective populations are evaluated, vaccine efficacy against HPV-16 and -18-related CIN2+ remains at 100%. As this vaccine is used over time in universal prophylactic HPV-16/18 vaccination of girls and women, reductions in cervical cancers at both the individual and public health levels will be appreciated."

Email the Press Complaints Commission?

Let's not have another MMR-esque tabloid frenzy, please.

Let's not have another MMR-esque tabloid frenzy, please.

their little babies won't be sleeping around when they are older because they are going to bring them up right.

I have express plans to go round finding the daughters of these people when they're older. They'll be dangerously repressed, or ridiculously pervy. It'll be great fun either way.

If you look up Dr Harper on google you will find she has been quoted in many other places expressing her concerns.

Oh for...

Dr Harper did indeed express the concerns as quoted and I read the story over to her before publication to make sure she was happy with it.

Dr Harper, of the University of Missouri-Kansas, said she believed the risks – “small but real” – could be worse than the risk of developing cancer itself.

According to Dr. Harper, assessing the true adverse event risk of Gardasil, and comparing it to the risk of cervical cancer can be tricky and complex. "The number of women who die from cervical cancer in the US every year is small but real. It is small because of the success of the Pap screening program."

How can she say "it may be more deadlier than the disease"

How can she say "it may be more deadlier than the disease" or "the risks outweigh the benefits" if, you know, nothing backs that up?

Well quite. You should be struck off for writing for the Express.

One supposes that if current death rate for cervical cancer is say 1 in 1000 and the death rate due to complications of the vaccine is 0.3 in 1000 but you give teh vaccine to 10,000 people then that would work, I think that's the point, maybe.

Well, THEN the vaccine would kill more than the disease.

Only if you are still looking at the 1000 people with cancer.

Malc

I'm not doubting the journalists integrity for a moment, I'm just somewhat surprised that Dr Thingy has seemingly gone off and done a laod of research, published it at least twice, in two different journals, and then changed her mind over iot all and gone "DANGEROUS! BAD!"

I'm avoiding libel as best I can.

add some cunts and you're fine.

I'm avoiding libel as best I can.

Also - gratuitous insult defence.

Either the Express is lying to you to shut you up, or they "compensated" her well for her change of opinion because they couldn't get any other scientists to support they campaign with suitable quotes...

It's not libel if it's true. Also - gratuitous insult defence. Just add some "cunt"s and you're fine.

Don't want to sidetrack the thread too much, but can you explain what this is in as many or few words as you see fit silver plate?

Look it up for yourself, you cunt.